Do not raise your dose or use this product or service additional generally or for for a longer period than prescribed. Your ailment will likely not increase any quicker, and also your danger of Uncomfortable side effects will maximize.

e., several copies on the gene for cytochrome P450 isoenzyme 2D6 or higher morphine concentrations). Young children with snooze apnea can be notably delicate to your respiratory depressant results of codeine.

Opioids can lessen the efficacy of diuretics by inducing the discharge of antidiuretic hormone. Watch patients for indications of diminished diuresis and/or results on blood pressure and boost the dosage of the diuretic as required.

Tell your medical doctor Should your cough does not get better in 5 times. Also, convey to your doctor if your condition will get even worse, or In case you have a headache that does not disappear, fever, or rash. These might be indicators of a serious clinical issue and should be checked by a physician.

Human Data Revealed facts from situation-Management and observational experiments on codeine use through pregnancy are inconsistent within their results. Some scientific tests of codeine exposure confirmed an increased chance of All round congenital malformations while others didn't.

Clearance might be diminished and the metabolites might accumulate to Substantially bigger plasma ranges in people with renal failure in comparison with sufferers with normal renal operate.

Neuroleptic malignant syndrome (NMS) which can lead to Dying. Show you Health care company straight away When you have any of the following signs and symptoms of NMS:

The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and slightly soluble in Liquor.

Bluish lips or pores and skin chills clay-coloured stools chilly sweats confusion cough dim urine lower in the frequency of urination decrease while in the urine quantity diarrhea difficult or troubled breathing issues in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when having up from lying or sitting down situation rapid, pounding, or irregular heartbeat or pulse experience of warmth fever headache superior fever hives or welts, itching, or rash enhanced sweating irregular, rapidly or sluggish, or shallow respiration substantial, hive-like swelling on the facial area, eyelids, lips, tongue, throat, fingers, legs, toes, or intercourse organs loss of urge for food lack of bladder control nausea noisy respiration not breathing distressing urination pale or blue lips, fingernails, or pores and skin rectal bleeding redness with the face, neck, arms, and occasionally, upper chest redness on the pores and skin viewing, Listening to, or emotion issues that aren't there seizures extreme muscle mass stiffness shakiness from the legs, arms, or arms stomach pain perspiring tightness during the chest tiredness trembling or shaking with the fingers Promethazine codeine syrup or toes unpleasant breath odor strange tiredness or weakness unusually pale skin vomiting of blood yellow eyes or skin Get emergency help right away if any of the subsequent indicators of overdose arise:

Codeine Carcinogenicity scientific tests ended up executed with codeine. Two-year studies in F344/N rats and B6C3F1 mice were being carried out to evaluate the carcinogenic prospective of codeine. No evidence of tumorigenicity was noticed in male and female rats at codeine dietary doses as many as 70 and eighty mg/kg/day (about comparable to 15 and 20 moments, the MRHD on the mg/m2 foundation, respectively).

g., amiodarone, quinidine) may well cause an increase in codeine plasma concentrations as well as a reduce in Lively metabolite morphine plasma concentration which could bring about an analgesic efficacy reduction or signs or symptoms of opioid withdrawal.

Since narcotic analgesics could enhance biliary tract force with resultant increases in plasma amylase or lipase ranges, perseverance of those enzyme ranges can be unreliable for twenty-four hours following a narcotic analgesic has actually been given.

Promethazine and codeine may perhaps trigger marked drowsiness or could impair the psychological and/or physical skills needed for your performance of potentially dangerous duties, like driving a automobile or running machinery.

are pregnant or prepare to be Expecting. Promethazine Hydrochloride and Codeine Phosphate Oral Solution can hurt your unborn baby. See “Exactly what is The most crucial information I should really find out about Promethazine Hydrochloride and Codeine Phosphate Oral Alternative?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and could potentially cause serious Unwanted side effects within your newborn which include greater sleepiness, respiratory troubles (respiratory despair), and death. It's not necessarily recognized if promethazine can pass into your breast milk.